Khaspekova et al. analyzed the platelet response among patients with acute coronary syndrome and found that the expression of platelet GPIb and GPIIbIIIa correlated with the average volume of platelets and not the genetic polymorphism of the GPIIIa Leu33Pro and GPIbα Thr145Met mutations.29 This evidence concerns the gene ITGB3 and acute coronary syndrome.