We further confirmed that mitochondrial HA-Bcl-xL-ActA and HA-Bcl-xL-NES prevented N134 tumour cells from apoptosis following etoposide treatment as wild-type Bcl-xL did, and nuclear HA-Bcl-xL-3x NLS failed to do so (Fig. 8c). The gene discussed is BCL2L1; the disease is neoplasm.