To determine whether HERG1 expression could be regulated by epigenetic mechanisms, we treated HNSCC cells with either demethylating agent 5-aza-2′-deoxycytidine (AZA), the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) or combinations. The gene discussed is KCNH2; the disease is head and neck squamous cell carcinoma.