In addition, the expression of HERG2, HERG3 and other potentially oncogenic Kv channels such as Kv1.3, KCa3.1 and Kv3.4 was also assessed in a panel of HNSCC-derived cell lines, as well as the contribution of histone acetylation to the regulation of aberrant Kv gene expression in HNSCC. The gene discussed is KCNN4; the disease is head and neck squamous cell carcinoma.