Mean baseline DKK-1 level was higher among RA patients with than without radiological progression within the first year of follow-up (29.6 ± 13.3 vs 26.63 ± 12.4 pmol/L) (p = 0.0084) and within the first 2 years of evolution (29.5 ± 13.1 vs 26.0 ± 11.7 pmol/L; p = 0.0027). Here, DKK1 is linked to rheumatoid arthritis.