On multivariate analysis adjusted for factors with significant or possible association with DKK-1 level on univariate analyses (DAS28, PGA, smoking status, and levels of several cytokines), only CRP level, presence of typical erosions related to RA and MCP-1 level remained associated with DKK-1 level (Table 3). The gene discussed is DKK1; the disease is rheumatoid arthritis.