It is worth noting that the SNP rs12229654 at MYL2 and its related SNP rs671 at ALDH2 were associated with every obesity trait analyzed (WCadjBMI, WHRadjBMI, WCnoBMI, and WHRnoBMI), with larger effects observed in men. Here, MYL2 is linked to obesity due to melanocortin 4 receptor deficiency.