Consistent with previous reports from European populations, we found evidence for multiple loci with significant sex differences for abdominal obesity in East Asians, with a generally more prominent effect in women, although larger effects in men than in women were observed for loci EFEMP1, MYL2/ALDH2, and FGFR4. Typically, men have more visceral fat, whereas women have more subcutaneous fat. This evidence concerns the gene MYL2 and Abdominal obesity.