GAPDH has also been implicated in the neuronalcell death observed in neurodegenerative diseases, such as Parkinson’s, Huntington’s,and Alzheimer’s diseases (18,20, 21, 22, 23, 24, 25-26).Although both GAPDH and Hcy are strongly involved in neurodegenerative diseases,especially neuron cell apoptosis, no study has established a clear link between the twofactors in connection with programmed cell death. This evidence concerns the gene GAPDH and early-onset autosomal dominant Alzheimer disease.