Furthermore, it has been shown that the serum levels of TGF-β1, NF-κB, and IL-6 were significantly elevated in the samples from cirrhosis rats while SM (50 g/kg) significantly prevented the aforementioned changes [223] and SM (250 mg/kg/BW) suppressed NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs [224,225]. The gene discussed is NFKB1; the disease is Cirrhosis.