However, positive correlation was observed between Ki-67 and N stage and M stage as illustrated in Table 3, statistical analysis revealed that the SIRT3, SIRT4, MTUS1, OGG1-2a and Ki-67 expression levels in head and neck cancer patients is associated with lymph node status and metastasis status of HNSCC cases. This evidence concerns the gene MTUS1 and head and neck squamous cell carcinoma.