One step forward, expression levels of OGG1-2a was correlated with expression levels of mitochondrial tumor suppressor genes such as SIRT3, SIRT4 and MTUS1 gene by spearman correlation coefficient and a significant positive correlation was observed between OGG1-2a and SIRT3, SIRT4 and MTUS1 genes which shown that OGG1-2a activity is regulated by SIRT3, SIRT4 and MTUS1 genes. Here, SIRT3 is linked to neoplasm.