Furthermore, significant negative correlation was also observed between SIRT3 versus M stage (-0.30***, p<0.001), SIRT4 versus M stage (-0.185*, p<0.04), MTUS1 versus M stage (-0.289**, p<0.001), OGG1-2a versus M stage (0.216*, p<0.03) and Ki-67 versus M stage (0.24**, p<0.008) in HNSCC cases as shown in Table 2. The gene discussed is SIRT4; the disease is head and neck squamous cell carcinoma.