In a recent combination study to assess the effects of targeting both oxidative stress and apoptotic pathways using a combination of the antiapoptotic c-Jun N-terminal kinase (JNK) inhibitor and the antioxidant neuroglobin (Ngb), combined treatment reduced infarct and improved neurological outcome more than single therapy after in vivo experimental stroke in hypertensive rats [193]. This evidence concerns the gene NGB and Stroke.