Injections of interleukin-6 (IL-6) before and after middle cerebral artery occlusion in mice restored activity of STAT3 and additionally restored the transcriptional activity of the Mn-SOD promoter through recovery of the recruitment of STAT3 to the Mn-SOD promoter; a resulting reduction in infarct volume was observed [133]. The gene discussed is SOD2; the disease is medical procedure.