RHBDF2 and Alzheimer disease: Most importantly, among these differentially methylated genes with an impact on gene expression in AD (Supplementary Table S1), we confirmed two recently discovered epigenetic targets of the disorder: ankyrin 1 (ANK1) and rhomboid 5 homolog 2 (RHBDF2).9, 10 We also further found differential methylation of ANK1 in DLB (Supplementary Table S3).