These findings are linked to the recent observation that amyloid peptide treatments can induce DNA methylation alterations in genes involved in in vitro neuronal differentiation.35 Other pathways associated with neurodegenerative diseases, such as altered cyclic nucleotide signaling,36 illustrated by the protein kinase cAMP-dependent regulatory type I alpha (PRKAR1A) and the cGMP-dependent protein kinase type II (PRKG2) genes, were also present in the identified DMRs. Here, PRKAR1A is linked to neurodegenerative disease.