Cardio-facio-cutaneous syndrome (CFCS) is one of the RASopathies and is characterized most commonly by genetic mutations in MEK1, MEK2 or BRAF. Cardiac abnormalities are among the most common findings in CFCS [18], including HCM in approximately 40% of patients [19]. The gene discussed is BRAF; the disease is cardiofaciocutaneous syndrome 1.