SRC (v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)) a tyrosine kinase is a very generic gene/protein, which controls a wide variety of processes, pathways, and actions, and is responsible for key events in the body, we found it to be the first-level neighbor to 13 already known Alzheimer’s disease genes (ADRBK1, AR, CASP3, CDH1, JAK2, JUN, NFE2L2, NOS1, PECAM1, SP1, STAT1, STAT3 and VAV1). Here, NOS1 is linked to early-onset autosomal dominant Alzheimer disease.