15 out of 48 SDEGs (CAMK4, CDK5R1, DCN, GRIN2A, HSPB2, ICAM2, JAK2, LMO4, NEFL, NEFM, PECAM1, PSEN1, SMAD3, SYN1 and TGFBI) are already associated in Alzheimer’s disease pathology. Here, DCN is linked to early-onset autosomal dominant Alzheimer disease.