From shortest-path network assessment, being first-level interacting partners with three or more already known AD-related genes we conclude that connecting genes/proteins added by the Pathway Studio software such as ESRRA, NRF1, PTK2B, SRC and SRF could also be of potential interest in Alzheimer’s disease domain. The gene discussed is NRF1; the disease is early-onset autosomal dominant Alzheimer disease.