15 out of 48 SDEGs (CAMK4, CDK5R1, DCN, GRIN2A, HSPB2, ICAM2, JAK2, LMO4, NEFL, NEFM, PECAM1, PSEN1, SMAD3, SYN1 and TGFBI) are already associated in Alzheimer’s disease pathology. The gene discussed is CDK5R1; the disease is early-onset autosomal dominant Alzheimer disease.