JAK2 and early-onset autosomal dominant Alzheimer disease: 15 out of 48 SDEGs (CAMK4, CDK5R1, DCN, GRIN2A, HSPB2, ICAM2, JAK2, LMO4, NEFL, NEFM, PECAM1, PSEN1, SMAD3, SYN1 and TGFBI) are already associated in Alzheimer’s disease pathology.