APP and early-onset autosomal dominant Alzheimer disease: Deregulation of APP, BACE1 (beta-site APP-cleaving enzyme 1) and PSEN1 are well-known causes of Alzheimer’s disease where APP and PSEN1 mutations are associated with familial form of the disease and BACE1 gene codes for one of the proteases that cleaves APP whose accumulation is the hallmark of Alzheimer’s disease.