Vitis vinifera ethanolic extract was found to have a significant protective effect by lowering the serum levels of alkaline phosphatase and total bilirubin [52], while resveratrol significantly decreased oxidative stress and hepatic inflammation (NF-κB and IL-1β ) in streptozotocin (STZ)-induced Type 1 diabetic rats [53]. The gene discussed is IL1B; the disease is type 1 diabetes mellitus.