Fu et al., 2014 has shown increase in the level of ANGPTL8 in obesity while [21] while Gomez-Ambrosi et al., 2014 showed reduction [24].We have recently showed that ANGPTL8 was increased in Type 2 diabetes and its level was correlating positively with obesity [15]. This evidence concerns the gene ANGPTL8 and obesity due to melanocortin 4 receptor deficiency.