The reduced PAI-1 activity in our study was at odds with the findings of a previous study [7], in which PAI-1 activity was found to increase with iohexol; the major difference between the two studies was the patient group (suspected pulmonary embolism as opposed to coronary artery disease) and it is plausible that fibrinoloyic factors could be differentially affected in these quite diverse patient groups. The gene discussed is SERPINE1; the disease is coronary artery disorder.