Harmine treatment of murine BCC cells reduced Gli1 expression in a concentration-dependent manner (Figure 2D and Figure S2), and like in human medulloblastoma cells, RNAi mediated perturbation of Dyrk1b efficiently inhibited Gli1 protein expression, while depletion of Dyrk1a did not. The gene discussed is DYRK1A; the disease is skin basal cell carcinoma.