The Hedgehog (HH)/GLI pathway plays a central role in the control of vertebrate development and tissue homeostasis of adult mammalian organisms, while its uncontrolled activation or inefficient termination has been implicated in a number of human malignancies including cancers of the skin, brain, hematopoietic system, lung, ovary and of the gastrointestinal tract [1]. The gene discussed is GLI1; the disease is skin neoplasm.