In addition, in HCC cells, miR-675 was found to mediate epithelial reprogramming through inhibition of TWIST1 expression, and miR-675 overexpression resulted in altered cellular morphology, reduced invasive potential, and increased anchorage-independent growth capacity and TWIST1 was identified as a direct target of this miR [171]. This evidence concerns the gene TWIST1 and hepatocellular carcinoma.