Interestingly, miR-205 was also identified as a very significantly upregulated miRNA in esophageal squamous cell carcinoma (ESCC) affecting cell migration and invasion and also targeting ZEB2, but contrary to the norm, was found to be elevated in these tumor cells, although the authors still project it as a tumor suppressor miRNA [99]. This evidence concerns the gene ZEB2 and esophageal squamous cell carcinoma.