NOS2 and periodontitis: Treatment with this compound in non-toxic concentrations revealed a strong inhibitory effect on NO production without affecting iNOS expression in murine macrophage-like cells (RAW 264.7 cells) stimulated with LPS of Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) or Fusobacterium nucleatum, two major bacteria implicated in periodontitis [60].