The results of this analysis demonstrated that the level of SPARC mRNA expression in the tumor transplants generated from 3 of the 4 SPARC transfected As+3 and Cd+2 transformed cell lines (As#3, Cd#1, Cd#4) was significantly reduced when compared to both the SPARC-transfected cell line and to levels present in the parental UROtsa cells (Fig 1A). Here, SPARC is linked to neoplasm.