At six weeks after AAA induction, Trail was detected weakly in most SMCs of the media of Opg-KO mice, but strongly in some SMCs, particularly those located at the peripheral edge of the medial layer and elastic fibers, in both wild-type (Fig 2C-A, 2C-B and 2C-C and S4A–S4E Fig) and Opg-KO mice (Fig 2C-F, 2C-G and 2C-H and S4F–S4J Fig). This evidence concerns the gene TNFRSF11B and triple-A syndrome.