Together with our previous study, which showed only a 46% [33] and 30% [13] suppression of diabetes in mice fed CTB-insulin at 35 weeks of age, as compared with 62% suppression of diabetes in mice fed CTB-Ins-GAD (62% vs 46%, p<0.05; 62% vs 30%, p<0.05). This evidence concerns the gene GAD1 and diabetes mellitus.