We assessed the effects of increasing levels of IC87114 on T cells from diabetes-prone NOD mice in in vitro culture, looking at anti-CD3 and anti-CD28 induced proliferation of CD4+ T cells (Fig 1A, left hand panel) and CD8+ T cells (Fig 1A, right hand panel) and production of IFN-γ (Fig 1B). Here, CD28 is linked to diabetes mellitus.