CD4 and diabetes mellitus: As production of IFN-γ was further decreased in BDC2.5 CD4+ T cells in vitro when CTLA4-Ig was added to IC87114 in culture, we tested whether oral administration of IC87114 in combination with CTLA4-Ig could prevent or delay onset of diabetes in NOD scid mice after transfer of BDC2.5 CD4+ T cells (Fig 6A).