As production of proinflammatory cytokines is central to the process whereby islet-specific T cells cause type 1 diabetes through incapacitating and killing beta cells [30], we wanted to test whether oral administration of IC87114 could prevent or delay onset of diabetes in NODscid mice after transfer of potentially diabetogenic islet-specific BDC2.5 CD4+ T cells. The gene discussed is CD4; the disease is diabetes mellitus.