Neither treatment with CTLA4-Ig on its own nor in combination with IC87114 affected development of diabetes after transfer of Th1 differentiated effector BDC2.5 CD4+ T cells into wt NOD mice (Fig 7C), as all mice regardless of treatment developed diabetes 5 to 6 days after injection of the diabetogenic cells. This evidence concerns the gene CTLA4 and diabetes mellitus.