However, we found that, despite seeing considerable inhibition of pro-inflammatory cytokine production even at the lowest concentrations of IC87114 tested, treatment with IC87114 had no effect on the development of diabetes either after adoptive transfer of naïve BDC2.5 CD4+ T cells into NOD scid mice or after transfer of Th1 differentiated effector BDC2.5 CD4+ T cells into wild type NOD mice. Here, CD4 is linked to diabetes mellitus.