Previous studies have not only found reduced flow mediated vasodilation [11, 13, 14], a measure of endothelial function, but also decreased CD34+ CD133+ CD31+ circulating progenitor cells (CPCs) cells with increased CD34+ CD45− endothelial colony forming cells (ECFCs) [15], an indicator of altered endothelial repair, in children and adolescents with T1DM. This evidence concerns the gene PROM1 and type 1 diabetes mellitus.