The transplantation tumor growth of pE6-R4-p53-TK/H1299 group was significantly inhibited, whose tumor inhibition ratio (86.41%) was significantly higher than 70.76% of pE6-p53-TK/H1299 group, 35.53% of pR4-p53-TK/H1299 group, and 12.58% of H1299 group. The gene discussed is TKT; the disease is neoplasm.