In another study, IL-17A via activation of tumor progression locus 2 (TPL2) induced mitogen activated protein kinase (MAPK), c-jun N-terminal kinase (JNK), and signal transducer and activator of transcription (STAT) 3 signaling and cellular transformation in JB6 CI41 mouse epidermal cells and promoted MCF7 (human breast cancer cell line) tumorigenicity [28]. Here, MAP3K8 is linked to breast carcinoma.