In agreement with these studies, a significant positive correlation was detected between IL-10 and IL-12 in our study and a significant correlation coefficient was detected with the transaminase levels which were higher in all liver pathologies than in nondisease controls; the elevation was significantly recorded with disease progression suggesting that IL-10 and IL-12 could be used as an index to reflect the degree of inflammation in the liver with ultimate development of HCC. This evidence concerns the gene IL10 and hepatocellular carcinoma.