MYC and neoplasm: For instance, while EAC presents at the genomic level as a tumour with some of the highest levels of chromosomal aberrations including copy number variation (CNV) and single nucleotide variation (SNV), those arising in immunodeficient mice from cells transformed in vitro with SV40 large T antigen, c-Myc and hTERT showed considerably fewer changes (Supplementary Fig. 7).