DENND2D and non-small cell lung carcinoma: From result showed in Fig. 8, we demonstrated that miR-mask designed to be fully complementary to the target DENND2D sequence of miR-522 reversed the effects of miR-522 on NSCLC cell proliferation and metastasis, indicating that miR-522 may function as an oncogene in NSCLC cells by directly targeting DENND2D.