IHC staining of subcutaneous tumour sections confirmed that OHT regulated the subcellular localization of AURKA (Fig. 6c upper panel; image 2/4 compared with image 1/3), and that VX-680 suppressed AURKA phosphorylation at T288 (Fig. 6c lower panel; image 3/4 compared with image 1/2). Here, AURKA is linked to neoplasm.