CDH1 and Patent ductus arteriosus: In contrast, while Pten∆f:p53R270H primary spindle tumors were largely negative for E-cadherin, lung metastases expressed significantly more of this transmembrane glycoprotein than primary lesions; PDA primary tumors were positive for E-cadherin to varying degrees, and this was largely preserved in metastatic counterparts (Fig. 7f-g).