In tumours, HIF‐1α promoted the expression of transforming growth factor (TGF)‐β, LOX, Snail, TWIST‐1, TCF‐3, ZEB1 (Zinc finger E‐box‐binding homeobox 1) and ZEB2, which then activated EMT and the metastasis of tumour cells 31, 32, 33, 34. This evidence concerns the gene ZEB1 and neoplasm.