Finally, considering that activation of PRRs, such as TLR3, might be associated with pain and psychiatric and neurodegenerative diseases [2, 9–11], it could be speculated that COX-2, mPGES-1, and PGE2 induced by this stimulus could partially contribute to the development of neuropathological conditions. The gene discussed is PTGS2; the disease is neurodegenerative disease.