KDR and neoplasm: The most remarkable outcome of single scVEGF/177Lu injection was a long-term sustainable vascular regression and, particularly, the decline in the prevalence of VEGFR-2 overexpressing cells in tumor vasculature; the effects were only transient in mice treated with conventional anti-angiogenic VEGF/VEGFR inhibitors, bevacizumab, or sunitinib [22].