The current results qualify our previous study, suggesting a trend (P=0.076) towards reduced survival of patients with strong YBX1 cytoplasmic staining in an independent set of 118 CRC samples and a significant correlation between high nuclear staining and reduced survival in pulmonary metastases (P=0.005).29 We suggest that correlations between nuclear YBX1 and patient outcome currently cannot be established in primary CRC possibly owing to the fact that YBX1 translocation to the nucleus is transient and considerably rare in non-metastatic colonic tissue specimens. This evidence concerns the gene YBX1 and colorectal carcinoma.