EGFR and lung cancer: In lung cancer, nuclear localization of YBX1 is correlated with EGFR and LRP (lung resistance protein) expression.28 In colorectal cancer (CRC), YBX1 has been identified as a prominent mediator of malignant properties downstream of the EGFR–RAS–MAPK signaling cascade.29 NFY/YBX1-binding sites were overrepresented among RAS/MAPK target genes, YBX1 binding was enhanced on a group of RAS/MAPK target genes in KRAS-transformed CRC cells and nuclear YBX1 staining was detected in lung metastasis of CRC.