Other reports also describe low percentages of nuclear YBX1 using immunohistochemistry in breast cancer cohorts23, 40 The overall (cytoplasmic plus nuclear) presence of YBX1 seemed sufficient for establishing prognostic relevance in several tumor entities.41, 42, 43 A separate assessment of nuclear and cytoplasmic staining might not be necessary. The gene discussed is YBX1; the disease is breast cancer.