YBX1 and neoplasm: SiRNA-dependent knockdown unraveled a functional role of YBX1 in tumor invasion, proliferation and apoptosis.18, 24, 25 YBX1 is involved in chemotherapy response.18, 19, 26 Intracellular localization is essential for YBX1 function and a complex regulation underlies the translocation of YBX1 between cytoplasm and nucleus.