These previous findings, combined with the dramatic reductions in brain 2-AG, AA, and prostaglandins observed in Dagla–/–mice (Figure 5A–D) and the substantial suppression of inflammatory responses in Daglb–/–microglia (Figure 4), motivated us to test whether microglial activation, a common feature of diverse nervous system diseases (Aguzzi et al., 2013), was regulated by DAGL enzymes in vivo. The gene discussed is DAGLB; the disease is nervous system disorder.