Because of the pivotal role of Snap25 in insulin release [2–6] we evaluated a possible role of three Snap25 polymorphisms (rs363039, rs363043, and rs363050) that are localized within intron 1 in a region spanning about 13.8 kb and are known to affect the gene expression in vitro [7, 8], in type 2 diabetes mellitus (T2DM). Here, INS is linked to type 2 diabetes mellitus.