RASSF1 and neoplasm: The univariate analysis performed so far allowed us to assess the performance of methylated RASSF1A as a marker of tumor-related cell-free DNA in melanoma for diagnostic purposes being able to discriminate the in situ and invasive melanomas from controls and as an indicator of patients prognosis, as assessed by the good discriminative power of the ROC curve including invasive and metastatic patients.