Protein inclusions in ALS form in the cytoplasm of degenerating motor neurons and depending on the patient, contain primarily [Cu/Zn] superoxide dismutase 1 (SOD1), TAR DNA binding protein 43 (TDP-43), fused in sarcoma (FUS), or by dipeptide repeat proteins produced by non-conventional repeat associated non-ATG translation, encoded by the Chromosome 9 open reading frame 72 repeat expansion (C9orf72) (Ferraiuolo et al., 2011; Turner et al., 2013; Leblond et al., 2014; Renton et al., 2014). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.