PDI also co-localizes with inclusions formed by other ALS-linked proteins, TDP-43 (Honjo et al., 2011; Walker et al., 2013), FUS (Farg et al., 2012) and vesicle associated membrane protein (VAPB) (Tsuda et al., 2008), implying that PDI is linked to general protein misfolding in ALS. This evidence concerns the gene P4HB and amyotrophic lateral sclerosis.