Upregulation of caspase-12 in CJD cell models and post-mortem patient cortex tissues (Hetz et al., 2003).Upregulation of ERp57, Grp94 and BiP in HD cell models and patient cortex tissues (Hetz et al., 2003). Increased intracellular calcium release from the ER (Torres et al., 2010). This evidence concerns the gene HSP90B1 and Creutzfeldt Jacob disease.