PDI overexpression in brains of CJD patients (Yoo et al., 2002).Increased expression of ERp57 (Hetz et al., 2005).ERp57 overexpression protects cells from PrPsc toxicity and decreases rate of caspase-12 activation (Hetz et al., 2005). The gene discussed is P4HB; the disease is Creutzfeldt Jacob disease.