TP53 and cancer: The p53 mutation or loss-of-function promotes EMT of cancer cells by increasing the expression of Snail1 protein as the miR-34 family of miRNAs suppresses Snail1 activity when it binds to highly conserved 3’-untranslated region in Snail1 and its regulatory molecules, including β-catenin, LEF1, and Axin2.