This phenomenon mostly involves gonadal, adrenal, and somatotropic axes, with a subsequent decline in testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), and IGF-1 concentrations, respectively [30], resulting in anabolic deficiency, an important determinant of accelerated aging process [30]. The gene discussed is IGF1; the disease is hyperinsulinemic hypoglycemia, familial, 4.