Various strategies must be considered to develop a better malaria vaccine, including the optimization of immune responses and immune memory against well-known and well-characterized targets like Pf CSP, by testing different presentation strategies (e.g., viral vectored vaccines, virus-like particles), formulations (virsosomes), delivery, and immunization schemes, as well as the identification of alternative and/or additional antigens to target the blood and sexual stages of the parasite life cycle to overcome allelic diversity and also to prevent immune evasion. The gene discussed is DNAJC5; the disease is malaria.