Tumor necrosis factor receptor superfamily member (TNFRSF14) also called Herpes virus entry mediator (HVEM), which interacts with B and T lymphocyte attenuator (BTLA) and downregulates lymphocyte activation and homeostasis (91), is altered in normal females when compared to males, as well as in SLE patients when compared to normal controls (90). The gene discussed is BTLA; the disease is systemic lupus erythematosus.