Interestingly, in the face of pathogenic infection or an inflammation caused by the resident microbiota, the IL-10 secreting Treg cells are also converted to IL-17, Retinoic acid-related Orphan Receptor (RORγT), and Interferon (IFN-γ) producing TH17 cells (Xu et al., 2007) and vice–versa (Gagliani et al., 2015). Here, IFNG is linked to infection.