IRS1 and Insulin resistance: It is known that activation of the renin-angiotensin system may lead to insulin resistance in the vasculature (Folli et al., 1997); Ang-II impairs insulin receptor intracellular signaling, inhibiting insulin receptor substrate-1 (IRS-1) phosphorylation and phosphatidylinositol (PI) 3–kinase activation (Folli et al., 1997; Cizmeci and Arkun, 2013).