However, in a murine model of alcoholic neutrophilic hepatitis, the lack of osteopontin failed to prevent alcoholic hepatitis, enhanced the expression of IL-17, and increased the number of polymorphonuclear cells infiltrating the liver potentially pointing to a more complex function of Osteopontin in formation of liver insult (Lazaro et al., 2015). The gene discussed is SPP1; the disease is alcoholic hepatitis.