TGFB1 and Hepatic fibrosis: Application of a specific tetra-peptide (Leu-Ser-Lys-Leu) derived from the latency-associated peptide of TGF-β prevented the progression of hepatic fibrosis in a DMN model in rats through inhibition of TGF-β1 activation and its downstream signaling (Kondou et al., 2003).