For therapy of hepatic fibrosis, the RGD peptide has attracted much interest because this peptide is the predominant cell adhesive epitope to fibronectin and well known to bind preferentially and with high affinity to the integrin αvβ3.This integrin and other integrins play essential role in angiogenesis and in fibroblasts where they are central in differentiation, migration, and proliferation. Here, FN1 is linked to Hepatic fibrosis.