Mice that lacked FGFR4 were more prone to hepatic fibrosis, while mice that lacked FGF1 and FGF2 showed decreased liver fibrosis in the CCl4 model (Yu et al., 2002, 2003) These unexpected and somewhat contradictory findings suggest that FGF signaling offers some potential therapeutic clues for prevention or treatment of hepatic fibrosis. The gene discussed is FGF2; the disease is Hepatic fibrosis.