PDGFD and neoplasm: Most of the experimental studies suggest that the targeting of PDGF-B, PDGF-D, and PDGFRβ should be more effective in treatment of hepatic fibrosis, while the ligands that are more connected to the PDGFRα signaling branch are more relevant in tumor angiogenesis and maintenance of the tumor microenvironment that is necessary for progression to hepatocellular carcinoma (Oseini and Roberts, 2009).