We bred floxGLS1 mice with global inducible cre-deletor mice to generate GLS1 iHET mice, in which Tmx becomes an irreversible glutaminase inhibitor, and measured amphetamine-induced hyperlocomotion as a proxy for positive symptoms of schizophrenia (Arguello and Gogos, 2006; van Den Buuse, 2010). The gene discussed is GLS; the disease is schizophrenia.