Also, it has recently been shown that phosphatidylethanolamine regulates autophagy and longevity (Rockenfeller et al., 2015), and LC3 lipidation are involved in autophagy and lipid metabolism turnover (Singh et al., 2009), which could be related with tissue homeostasis and improvement of cognitive function of 3xTg-AD mice treated with BACE1miR during 6 and 12 months (Villamil-Ortiz and Cardona-Gomez, 2015). Here, MAP1LC3A is linked to Alzheimer disease.