Therefore, we evaluated whether LAMP-2A, a CMA-induced lysosome membrane receptor (Agarraberes et al., 1997; Cuervo and Dice, 2000a,b; Tanaka et al., 2000; Bampton et al., 2005; Kaushik et al., 2006; Kiffin et al., 2007; Bandyopadhyay et al., 2008), was also modulated by BACE1 knockdown in 3xTg-AD mice. The gene discussed is BACE1; the disease is Alzheimer disease.