Although, we did not detect changes of pSer473 AKT in hippocampi total lysates (Figure 8B), we detected high protein levels of p2448 mTOR and increased mTOR activity (Figure 8E) in the hippocampi of 3xTg-AD treated, without changes in pThr389 p70S6K with BACE1miR compared with the control values, (Figures 8C,D). Here, RPS6KB1 is linked to Alzheimer disease.