AKT1 and tauopathy: It is well documented that Hsp90 inhibitors (geldanamycin, radicicol, and their analogs) dephosphorylate and inactivate Akt (Fujita et al., 2002), which is associated with both tauopathy and cancer inhibition (Georgescu, 2010; Jimenez et al., 2011; Jinwal et al., 2011; Kannaiyan et al., 2011; Chen et al., 2012).