The CDK5 protein levels (Figure 3D), CDK5 activity (Figure 3E), GSK-β, GSK-β (Figure 3F), Bcl-2 (Figure 3G), ERK-1, ERK-2 (Figure 3H) and PP2A activity (Figure 3I) were not modified in BACE1miR-treated 3xTg-AD mice. Here, CDK5 is linked to Alzheimer disease.