Lysosome pathology in AD-affected brains involves changes in macroautophagy and increased APP proteolysis, and it contributes to Aβ deposition (Grbovic et al., 2003; Cataldo et al., 2004a,b; Yu et al., 2004; Nixon et al., 2005; Boland et al., 2008). The gene discussed is APP; the disease is Alzheimer disease.