Due to this complex phenotype, definite MSA diagnosis requires autopsy to detect glial cytoplasmic inclusions (GCIs) immunopositive for α-synuclein (α-syn) and neurodegeneration in striatonigral or olivopontocerebellar structures (Lantos, 1998; Trojanowski and Revesz, 2007; Gilman et al., 2008). Here, SNCA is linked to multiple system atrophy.