SOD1 and amyotrophic lateral sclerosis: The elevated amounts of iron deposits have been also reported in the brain and spinal cord of ALS patients (Kasarskis et al., 1995; Kwan et al., 2012; Ignjatović, 2013) and mice overexpressing mutated human SOD1 gene (Jeong et al., 2009; Lee et al., 2015).