First, examination of levels of Wnt7a protein expression in the 347 breast cancer cohort (Fig. 8b) revealed that overall patient survival is significantly reduced in the Wnt7a high versus the Wnt7a low group (P=0.0273 log-rank test; Fig. 8c), and that, by multivariate analysis, Wnt7a expression is an independent prognostic outcome marker (Fig. 8d). This evidence concerns the gene WNT7A and breast cancer.