Second, taking a complementary approach, we examined the fibroblast core serum response (F-CSR) signature described in ref. 37 as a surrogate measure of CAF activation in clinical data sets, and demonstrated a significant correlation between high WNT7A expression in human breast cancers and a high F-CSR score (P=2.56 × 10−5; Supplementary Fig. 8b). Here, WNT7A is linked to breast cancer.